Avandia is a type 2 diabetes oral medication in the thiazolidinedione (TZD) class of drugs. It helps insulin work better in muscle and fat cells and balances glucose production in the liver. This medication is only available in the brand name (Avandia). Because type 2 diabetes medications act in different ways to lower blood glucose levels, doctors will often prescribe multiple drugs. Several of the more popular combinations of oral drugs can be prescribed together in a single pill. Each medication has its own side effects; read labels carefully to be sure you know what they are.