Invokana (canagliflozin) is a type 2 diabetes oral medication in the SGLT-2 inhibitor class of drugs. It blocks glucose from being reabsorbed by the kidneys. Excess glucose is released in the urine. Medications in the SGLT-2 inhibitor class may offer heart and kidney benefits for people with cardiovascular disease. Talk to your doctor about your options and whether switching to one of these drugs may help you. Because type 2 diabetes medications act in different ways to lower blood glucose levels, providers will often prescribe multiple drugs to a patient. For example, a doctor might prescribe both a biguanide and a sulfonylurea. Several of the more popular combinations of oral drugs can be prescribed together in a single pill. Each medication has its own side effects. Read labels carefully to be sure you know what they are.